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EBV

TRAF1 Linked to Hodgkin's Disease

Published in Cancer Weekly, February 1st, 1999

Tumor necrosis factor receptor-associated factor 1 is consistently and strongly expressed in Epstein-Barr virus-induced lymphoproliferations and Hodgkin's disease, researchers reported.

The tumor necrosis factor (TNF) receptor-associated factor 1 (TRAF1) is a member of the recently defined TRAF family. The TRAF family is a group of molecules involved in the intracellular signal transduction of several members of the TNF receptor (TNFR) family, such as the TNF receptor 2 (TNFR2), the lymphotoxin-(beta) receptor (LT-(beta)R), the Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1), CD40, and CD30, noted Horst Durkop and colleagues of Germany's Freie...

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