"Simultaneous Protection of G156A Methylguanine DNA Methyltransferase Gene-Transduced Hematopoietic Progenitors and Sensitization of Tumor Cells Using O-6-benzylguanine and Temozolomide."

According to the authors' abstract of an article published in Clinical Cancer Research, "O-6-Benzylguanine (BG) potentiates temozolomide (TMZ) cytotoxicity in tumors by inactivating O-6-alkylguanine DNA alkyltransferase but also increases toxicity in hematopoietic cells. To improve the hematopoietic cell tolerance to alkylating agents, we retrovirally transduced the BG-resistant mutant G156A methylguanine DNA methytransferase gene (Delta MGMT) into hematopoietic progenitors and evaluated whether Delta MGMT expression in hematopoietic colony-forming units would result in greater drug resistance to TMZ. Delta MGMT expression in human and mouse colony-forming units followed by BG treatment...

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