Cancer Immunotherapy
"Generation of Tumor-Specific Cytotoxic T Lymphocytes against Cervical Cancer Cell Lines by In Vitro Stimulation with a Synthetic Human Papilloma Virus Type 16 E7 Epitope."
Published in Cancer Weekly, February 22nd, 1999
According to an abstract submitted by the authors to the conference Gene Therapy of Cancer VII, held November 19-21, 1998, in San Diego, California, "Introduction: More than 50% of squamous carcinomas of the uterine cervix are associated with human papilloma virus type 16 (HPV-16). Given the viral nature of cervical cancer, cell-mediated immunity is thought to be an important mechanism in protection against the virus and elimination of virus-infected cervical cancer cells. Objective: To generate histocompatibility leukocyte antigen (HLA) A2-restricted HPV-16 E7 peptide-specific cytotoxic T lymphocytes (CTL) in vitro for future adoptive immunotherapy. Materials and...
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Source: Cancer Weekly (1999-02-22)
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