Published in Cancer Weekly, February 22nd, 1999
Angiogenesis is an important step in the evolution of a benign tumor toward malignancy and metastasis. Tumor cells obtain such a phenotype by their ability to secrete angiogenic factors, such as vascular endothelial growth factor (VEGF). VEGF receptors (VEGFRs) flt-1/VEGFR-1 and Flk-1/KDR/VEGFR-2 are restricted to activated endothelial cells; the highest expression occurs in the tumor vasculature.
Naveen Arora, Center for Biochemical Technology, Delhi, India, and colleagues performed a study to target the VEGFRs ("Vascular...
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