Cancer Therapies (Endostatin)

Anti-Cancer Drug Enters New Phase

Published in Cancer Weekly, February 22nd, 1999

Government scientists have managed to duplicate Dr. Judah Folkman's success with an experimental cancer treatment that wipes out tumors in mice, and they plan to begin human testing by the fall.

The closely watched developments involve a natural protein called endostatin. It and a sister protein called angiostatin both work - at least in mice - by blocking tumors' ability to sprout new blood vessels. This makes cancer fall dormant or disappear altogether in lab animals. But no one knows if the same thing will happen in people.

The two proteins have been the subject of a roller coaster of speculation ever since an enthusiastic front-page story in...

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Source: Cancer Weekly (1999-02-22)

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