Virology

Suramin May Block HCV Binding to Hepatoma Cells

Published in Cancer Weekly, March 8th, 1999

The polysulphonate suramin appears to block hepatitis C virus binding to human hepatoma cells in vitro.

It was recently demonstrated that the binding of dengue virus to its target cell receptor could be effectively blocked by both heparin and by the polysulphonate pharmaceutical, Suramin [Chen et al., Nature Medicine 1997;3:866-871].

"Because both dengue and hepatitis C virus (HCV) belong to the Flaviviridae and because the HCV envelope is predicted to possess a heparin-binding motif, we tested heparin, Suramin, and a number of other polyanionic compounds for their ability to block HCV binding in vitro," J.A. Garson and colleagues of London's...

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Source: Cancer Weekly (1999-03-08)

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