Angiogenesis Quantification
"Preclinical Evaluation of Intermediate Endpoints."
Published in Cancer Weekly, March 22nd, 1999
NIH Grant Number: 1N01CN85166. Grant Expires: September 29, 2000. Principle Investigator: John M. Pezzuto. Performing Organization: Medical College of Ohio at Toledo, Box 10008, Toledo, Ohio 43699. Description: An experimental model of proliferative retinopathy produced in response to ischemia-induced retinal neovascularization in mice (Smith et al., 1994) lends itself as an ideal system in which to quantitate angiogenesis. The system is well characterized and highly reproducible generating a quantifiable neovascular response in 100% of animals (Pierce et al., 1995). It has been shown that VEGF expression is upregulated during retinal...
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Source: Cancer Weekly (1999-03-22)
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