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Cancer Therapies (Animal Models)

Protein Discovery Might Improve Treatment

Published in Cancer Weekly, April 12th, 1999

University of North Carolina at Chapel Hill (UNC-CH) scientists have discovered they can shrink - and in many cases, eliminate - human tumors grown in laboratory animals by inhibiting a natural mechanism that prevents tumor cells from dying.

Although not yet tried directly in humans, scientists believe their technique could one day significantly improve survival among patients with many kinds of cancer. They are planning the first human tests, which should begin later in 1999.

The mechanism they've studied for more than three years involves NF-kappa B, a protein that attaches to DNA inside the nucleus of cells and turns genes on and off like a...

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