Cancer Immunotherapy
Naked DNA Cytokine Delivery Has Immune Modulating Effects
Published in Cancer Weekly, April 26th, 1999
T. Nomura and colleagues from Kyoto University, Japan, examined the antitumor effect of direct interferon-gamma (IFN-gamma) gene transfer into CT-26 tumors ("Gene Expression and Antitumor Effects Following Direct Interferon (IFN-gamma) Gene Transfer with Naked Plasmid DNA and DC-chol Liposome Complexes in Mice," Gene Therapy, 1999;6:121-9).
According to N.K. Egilmez et al., DC-chol liposome is one of the most efficient cationic liposomes for in vivo intratumor gene transfer (Biochem. Biophys. Res. Commun., 1996;221:169-73). Nomura et al. conducted...
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Source: Cancer Weekly (1999-04-26)
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