Published in Cancer Weekly, May 10th, 1999
E. Kievit and colleagues from the University of Michigan compared yeast cytosine deaminase (yCD) to bCD in a suicide gene therapy protocol ("Superiority of Yeast Over Bacterial Cytosine Deaminase for Enzyme/Prodrug Gene Therapy in Colon Cancer Xenografts," Cancer Research, April 1, 1999;59(7):1417-1421).
"The enzyme/prodrug strategy using bacterial cytosine deaminase and 5-fluorocytosine (5-FC) is currently under investigation for cancer gene therapy," wrote Kievit et al. "A major limitation for the use of...
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