Cancer Immunotherapy

Co-Delivery of Cytokines Boosts Immunization Efficacy

Published in Cancer Weekly, May 10th, 1999

Co-delivery of interleukin-12 (IL-12) gives gene gun immunization the boost it needs to induce effective antitumor immunity.

DNA-based immunization is a rapidly expanding area of vaccine research and development. It has enormous potential as an anticancer immunotherapeutic.

Current experimental strategies use recombinant viral vectors or nonviral plasmids. Nonviral plasmid DNA-based immunizations, however, have several clinically relevant advantages over viral vector strategies.

T. Tuting and colleagues from the University of Pittsburgh, Pennsylvania, and the J-Gutenberg University, Germany, characterized and compared the immune...

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Source: Cancer Weekly (1999-05-10)

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