Renal Cell Carcinoma
"Identification of Receptor Genes in Renal Cell Carcinoma Associated With Angiogenesis by Differential Hybridization Technique."
Published in Cancer Weekly, June 14th, 1999
According to the authors' abstract of an article published in Biochemical and Biophysical Research Communications, "To screen the receptor genes in renal cell carcinoma (RCC) associated with angiogenesis, we performed differential hybridization of the cDNA library of membrane-type protein tyrosine kinases (mPTKs). Three thousand plaques of a mPTKs-enriched cDNA library were screened with mPTKs mixture probes produced from hypervascular RCC tissues and RCC cell lines. Six different cDNA fragments of the PTK genes were isolated, and the sequence analysis showed that these represented cDNAs for TIE1, KDR, FMS, FGFR-4, JAK1, and HCK. Of these genes, the expression of TIE1, KDR, and FGFR-4...
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Source: Cancer Weekly (1999-06-14)
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