Cancer Immunotherapy
CTLs Circumvent Tumor Resistance To Apoptosis
Published in Cancer Weekly, July 12th, 1999
Because Fas and Fas ligand (FasL) have been found both in lymphoid and in non-lymphoid malignancies, and are thought to play a role in the interplay between tumors and the immune system, M. Ferrarini and colleagues from the Hospital San Raffaele, Italy, investigated Fas/FasL expression, function and intracellular signalling pathways in human melanomas ("Blockade of the Fas-Triggered Intracellular Signaling Pathway in Human Melanomas is Circumvented by Cytotoxic Lymphocytes," International Journal of Cancer, May 17, 1999;81(4):573-579).
"Of five melanoma cell lines, three...
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Source: Cancer Weekly (1999-07-12)
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