Vector Development

Coacervate Microspheres Deliver Viruses to Tumors

Published in Cancer Weekly, August 9th, 1999

Coacervate microspheres can encapsulate recombinant adenoviruses for delivery to tumor nodules.

S. Kalyanasundaram and colleagues from Birmingham, Alabama, investigated a novel gene delivery method ("Coacervate Microspheres as Carriers of Recombinant Adenoviruses," Cancer Gene Therapy, 1999;6(2):107-112).

"The therapeutic utility of recombinant adenoviruses (rAds) is limited in part by difficulties in directing the viruses to specific sites and by the requirement for bolus administration, both of which limit the efficiency of target tissue infection," wrote Kalyanasundaram et al. "As a first step toward overcoming these limitations, rAds were...

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Source: Cancer Weekly (1999-08-09)

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