Published in Cancer Weekly, August 23rd, 1999
H. John and colleagues isolated circulating elongated forms of the angiogenesis inhibitor and potential anti-cancer drug endostatin from human blood filtrate ("Novel Glycosylated Forms of Human Plasma Endostatin and Circulating Endostatin-Related Fragments of Collagen XV," Biochemistry, August 1999;38(32):10217-10224).
They identified immunoreactive endostatin by a polyclonal rabbit antiserum raised against an N-terminal epitope of the polypeptide and purified by consecutive chromatographic steps and immunoblotting.
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