Angiogenesis Inhibitors

Novel Glycosylated Forms of Endostatin

Published in Cancer Weekly, August 23rd, 1999

Novel glycosylated forms of endostatin and endostatin-related fragments of collagen have been isolated.

H. John and colleagues isolated circulating elongated forms of the angiogenesis inhibitor and potential anti-cancer drug endostatin from human blood filtrate ("Novel Glycosylated Forms of Human Plasma Endostatin and Circulating Endostatin-Related Fragments of Collagen XV," Biochemistry, August 1999;38(32):10217-10224).

They identified immunoreactive endostatin by a polyclonal rabbit antiserum raised against an N-terminal epitope of the polypeptide and purified by consecutive chromatographic steps and immunoblotting.

N- and...

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Source: Cancer Weekly (1999-08-23)

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