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Cancer Immunotherapy

Adoptive Immunotherapy Is Independent of Immunologic Specificity

Published in Cancer Weekly, August 30th, 1999

Adoptive immunotherapy requires down-regulation of L-selectin expression.

J. Kjaergaard and colleagues from the Cleveland Clinic Foundation, Ohio, used fluorochrome labeling to determine the early trafficking pattern of systemically transferred cells in adoptive immunotherapy. Results were reported in the Journal of Immunology ("Tumor Infiltration by Adoptively Transferred T Cells is Independent of Immunologic Specificity but Requires Down-Regulation of L-Selectin Expression," Journal of Immunology, July 15, 1999;163(2):751-759).

"Adoptive immunotherapy with anti-CD3/IL-2 activated tumor-draining lymph node (LN) T cells is capable of eradicating...

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