Cancer Gene Therapy

Fusion Proteins Can Have Immunomodulating Effect

Published in Cancer Weekly, September 13th, 1999

Fusion proteins can be used to convert B7-negative tumors into B7-positive tumors without gene transfer.

P. Holliger and colleagues from the University Klin Koln, Germany, demonstrated that displaying engagement sites for the T-cell antigens CD3 and CD28 on the surface of colon carcinoma cells is a suitable way to activate and retarget T cells in a highly tumor-specific manner.

Their data were reported in the journal Cancer Research ("Carcinoembryonic Antigen (CEA)-Specific T-Cell Activation in Colon Carcinoma Induced by Anti-CD3xAnti-CEA Bispecific Diabodies and B7xAnti-CEA Bispecific Fusion Proteins," Cancer Research,...

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Source: Cancer Weekly (1999-09-13)

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