Published in Cancer Weekly, September 20th, 1999
The picture shows how a cytodifferentiation agent, discovered by MSKCC researchers, closely fits into an enzyme and affects how it regulates cells. By visualizing how the drug, called SAHA, nestles into the active site of the enzyme and subtly alters its structure, the picture will enable investigators to make more potent and more specifically targeted versions of these drugs.
The first clinical...
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