Growth Factors

bFGF May Play Role Different from Previously Thought

Published in Cancer Weekly, September 20th, 1999

Basic fibroblast growth factor expression of stromal cells and vessels is inversely correlated with lymph node metastasis in non-small cell lung cancer, according to recent findings.

Tumor progression results from complex interactions between tumor and tumor-associated host issue. Basic fibroblast growth factor (bFGF), by way of activation of its receptor, FGFR-1, has been suggested to be an important inducer of host stromal response and angiogenesis.

Francesca Guddo and colleagues, University of Pisa, Italy, performed a study to assess the putative role of tumor-associated stromal cells and vessels in tumor progression ("The Expression of Basic...

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Source: Cancer Weekly (1999-09-20)

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