"Human Estrogen Receptor Transactivation by Hydroxytamoxifen on the VIT Regulatory Region in the ER-Negative PR-Positive Breast Cancer Cell Line EVSA-T."

According to an abstract submitted by the authors to the Sixth International Congress on Hormones and Cancer, held September 5-9, 1999, in Jerusalem, Israel, "Tam antagonizes estrogen-driven cell proliferation in breast cancers; inversely it acts as an estrogen on the uterus. ER regulates gene expression in a cell-specific manner. These properties seem to be implicated in this phenomenon. Whether such properties are relevant to breast cancer cells with different ER profiles was investigated. For that purpose, we analyzed transactivation properties of ER(alpha) in two breast cancer cell lines respectively with positive and negative ER pattern, MCF-7 (ER⁺/PR⁺) and...

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