Cervical Cancer (Prognostics)

Eosinophilic Infiltrates Result from Type II Immune Response

Published in Cancer Weekly, October 11th, 1999

Classifying eosinophilic tumor infiltrates may have implications for immunotherapy of cervical squamous carcinoma.

Studies have shown that the presence of an eosinophilic infiltrate in patients with cervical squamous carcinoma is correlated with a worse overall survival, suggesting a less effective immune response in these cases.

Since type 2 cytokines such as IL-4 and IL-5 are known to attract eosinophilic granulocytes, W.J. Vandriel and colleagues from Leiden University, The Netherlands, performed an immunohistochemical study to gain further insight as to whether a type 1 or type 2 immune response is involved in eliciting an eosinophilic...

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Source: Cancer Weekly (1999-10-11)

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