"Vascular Endothelial Growth Factor A (VEGF-A) mRNA Expression Levels Decrease after Menopause in Normal Breast Tissue but not in Breast Cancer Lesions."

According to the authors' abstract of an article published in British Journal of Cancer, "We hypothesized that the regulation of microvascular functions and angiogenesis in breast tissue, a well known target of ovarian steroid action, is dependent on the hormonal exposure of the breast. Relative expression levels of VEGF-A (vascular endothelial growth factor A), a putative key regulator of angiogenesis in breast cancer, were analysed in the tumour and the adjacent non-neoplastic breast tissue of 19 breast cancer patients by quantitative reverse transcriptase polymerase chain reaction. In non-neoplastic breast specimens the expression levels of all detected VEGF-A-isoforms (189, 165, 121)...

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