Published in Cancer Weekly, October 18th, 1999
Angiogenesis, the process whereby endothelial cells divide and migrate to form new blood capillaries, has been assessed in tumors by measuring microvessel density. High microvessel density is a significant adverse prognostic factor in breast cancer. The angiogenic factor, basic fibroblast growth factor (bFGF), has been associated with tumorigenesis and metastasis in several human cancers. There are few quantitative studies of bFGF expression in normal tissues compared to cancer, noted K. Smith and colleagues, John Radcliffe Hospital, Oxford,...
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