Colon Cancer (Anti-Angiogenesis)
"Inhibition of Angiogenesis and Intrahepatic Growth of Colon Cancer by TAC-101."
Published in Cancer Weekly, October 25th, 1999
According to the authors' abstract of an article published in Clinical Cancer Research, "We demonstrated in this study that inhibition of intrahepatic growth of colon cancer by TAC-101 is mediated by inhibition of angiogenesis. In vitro experiments showed that TAC-101 inhibited the proliferation of murine hepatic sinusoidal endothelial (HSE) cells induced by coculture with murine colon 26-L5 (L5) cells. HSE cell proliferation was also enhanced by conditioned medium of L5 cells (CR I-LS), and this enhancement of proliferation was abrogated by anti-vascular endothelial growth factor antibody. CM-LS also induced in vitro tube formation of HSE cells on Matrigel, and this activity of CM-L5...
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Source: Cancer Weekly (1999-10-25)
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