Diagnostics (Renal Cell Tumors)
Assay Detects Allelic Changes in Renal Tumors
Published in Cancer Weekly, October 25th, 1999
Renal cell tumors display notoriously intra- and intertumoral morphological heterogeneity, making a reproducible cytomorphological diagnosis impossible. To overcome the cytological heterogeneity, the "Heidelberg Classification of Renal Cell Tumors" is soundly based on the genetic lesions that underlie the formation of distinct tumors.
Allelic loss of chromosome 3 p and mutation of the VHL gene specify conventional renal cell carcinoma. In addition, duplication of chromosome 5 q as well as allelic losses of prognostic value...
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Source: Cancer Weekly (1999-10-25)
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