Ovarian Cancer (Pathophysiology)
Focal Adhesion Kinase Is Overexpressed in Ovarian Carcinoma
Published in Cancer Weekly, November 15th, 1999
"Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that is part of a signaling cascade stimulated by cell adhesion, motility, and growth. This tyrosine kinase, pp125FAK, initially was found to be tyrosine-phosphorylated in response to integrin-mediated cell adhesion, integrin clustering, and cell migration. Subsequently, FAK has been found to be activated by three oncoproteins: v-Sra, v-Crk, and Bar-Abl. Immunofluorescence studies indicate that the pp125FAK protein is...
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Source: Cancer Weekly (1999-11-15)
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