Colorectal Cancer (Pathogenesis)

Carcinogenesis Model for Colorectal Cancer Presented

Published in Cancer Weekly, November 22nd, 1999

Researchers in France have presented a simple model for carcinogenesis of colorectal cancers.

Lynch syndrome is a hereditary predisposition to colorectal cancer (CRC) and other cancers caused by germline mutations in mismatch repair (MMR) genes.

"Almost all the cancers diagnosed in Lynch syndrome have an acquired MMR deficiency, a replication error (RER) mutator phenotype that is also found in a minority of sporadic cancers developed in the target organs of Lynch syndrome," N. Janin from the Institut Gustave Roussy wrote ("A Simple Model for Carcinogenesis of Colorectal Cancers with Microsatellite Instability," Advanced Cancer Research,...

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Source: Cancer Weekly (1999-11-22)

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