Markers

Truncated HBV RNA Indicates Chronic Hepatitis

Published in Cancer Weekly, December 27th, 1999

Truncated hepatitis B virus RNA is a marker of chronic hepatitis infection but may or may not be a marker of liver cancer in older patients.

RNA from tissue samples of 46 HBsAg seropositive hepatocellular carcinoma (HCC) patients was analyzed by an RT/PCR assay which discriminates full-length hepatitis B virus (HBV) RNA polyadenylated at the unique viral poly(A) signal governing replication from truncated HBV RNA polyadenylated at a cryptic poly(A) signal.

In the tumor the apparent coexistence was less frequent than in the peritumor while the predominance of one of the two RNAs was more frequent. The mean age of patients with a predominance of...

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Source: Cancer Weekly (1999-12-27)

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