Published in Cancer Weekly, December 27th, 1999
Previously, L. Jadeski and colleagues discovered a positive correlation between the expression of nitric oxide synthase (NOS) and tumor progression. Treatment with inhibitors of NOS, N-G-methyl-L-arginine (NMMA) and N-G-nitro-L-arginine methyl ester (L-NAME), had antitumor and antimetastatic effects that were partly attributed to reduced tumor cell invasiveness.
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