Animal Models

Nitric Oxide Mediates C3L5 Tumor-Induced Angiogenesis

Published in Cancer Weekly, December 27th, 1999

Nitric oxide is a chief mediator of C3L5 tumor-induced angiogenesis, according to a recent report from Canada.

Previously, L. Jadeski and colleagues discovered a positive correlation between the expression of nitric oxide synthase (NOS) and tumor progression. Treatment with inhibitors of NOS, N-G-methyl-L-arginine (NMMA) and N-G-nitro-L-arginine methyl ester (L-NAME), had antitumor and antimetastatic effects that were partly attributed to reduced tumor cell invasiveness.

In the current study, Jadeski et al. examined the angiogenic role of NO in a highly metastatic murine mammary adenocarcinoma cell line by using a novel in vivo model of tumor...

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Source: Cancer Weekly (1999-12-27)

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