Vector Development
Optimized Vectors Improve Folate Receptor-Mediated Gene Therapy
Published in Cancer Weekly, January 11th, 2000
"A folate-targeted transfection complex that is internalized by certain cancer cells and displays several properties reminiscent of enveloped viruses has been developed," stated J.A. Reddy and colleagues, Purdue University, Department Chemistry, Indiana.
According to the researchers, these liposomal vectors are comprised of a polycation-condensed DNA plasmid associated with a mixture of neutral and anionic lipids supplemented with folate-poly(ethylene glycol)-dioleylphosphatidylethanolamine for tumor...
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Source: Cancer Weekly (2000-01-11)
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