Cancer Vaccines
Tyrosine Kinase Receptor is a Potential Angiogenic Target
Published in Cancer Weekly, February 1st, 2000
"Immune therapy of malignant tumors could be achieved by the destruction of the tumor vasculature," reported J. M. Ramage and colleagues from the Nottingham University and City Hospital, United Kingdom. "Our aim is to design a vaccine that results in the generation of T cells against tumor endothelial specific antigens."
According to the researchers, TKE is a possible candidate antigen. They predicted possible HLA-A2 epitopes unique to TEK. One of these is the peptide GMVEKPFNI. In order to increase the affinity...
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Source: Cancer Weekly (2000-02-01)
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