Cancer Gene Therapy

p21 Gene Transfer Induced Apoptosis in Esophageal Cancer Cells

Published in Cancer Weekly, February 8th, 2000

Adenovirus-mediated p21(Sdi1) gene transfer induced differentiation-dependent apoptosis in human esophageal squamous cell carcinoma, determined a study from Japan.

"When keratinocytes withdraw from the cell cycle, they migrate from the basal to the superficial layers of the epidermis and undergo morphological and biochemical changes during the process of terminal differentiation," stated Y. Kadowaki and colleagues from the Okayama University, School of Medicine, Japan. "These differentiation features of keratinocytes are known to be altered or reduced in esophageal cancer cells."

Therefore, the researchers examined the effects of transferring the...

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Source: Cancer Weekly (2000-02-08)

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