Cancer Gene Therapy

INF-(alpha) Combined with CD80 Transduction Reduces Tumorigenicity

Published in Cancer Weekly, February 22nd, 2000

Interferon-alpha (IFN-(alpha)) gene therapy in combination with CD80 transduction reduced tumorigenicity and growth of established tumor in poorly immunogenic tumor models, reported researchers from the United States.

"IFN-(alpha) or CD80 transduction of tumor cells individually reduces tumorigenicity and enhances antitumor responses," stated K. Hiroishi and colleagues from the University of Pittsburgh, Pennsylvania. "Here, we report that the combination of IFN-alpha and CD80 cancer gene therapy in poorly immunogenic murine tumor models, the colorectal adenocarcinoma cell line MC38, and the methylcholanthrene-induced fibrosarcoma cell line MCA205, reduces tumor growth...

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Source: Cancer Weekly (2000-02-22)

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