Cancer Gene Therapy

Apoptosis Induced by Adenovirus-Delivered Anti-bcl-2 Ribozyme

Published in Cancer Weekly, March 21st, 2000

Apoptosis was induced in oral cancer cells by the adenovirus-mediated delivery of an anti-bcl-2 ribozyme, researchers from the United States reported.

"Human oral cancer cells may have any of several genetic changes, but the role of the bcl-2 oncogene is relatively unexplored," stated S.A. Gibson and colleagues, State University of New York College of Medicine, New York, USA. "To find out if this gene plays a significant role and whether it could act as a target for gene therapy of oral cancer, we have examined the effects of an anti-bcl-2 ribozyme on the phenotype of oral cancer cells."

Gibson et al. published the results of their study in...

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Source: Cancer Weekly (2000-03-21)

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