Carcinogenesis

Mutations Not the Only Gene Defect that Leads to Cancer

Published in Cancer Weekly, March 28th, 2000

New research shows that gene mutations are not the only kinds of defects involved in the transformation of a healthy cell into a malignant one. Scientists say that this may mean the nature of cancer is even more complicated than once thought.

Another kind of defect, one that turns off genes without changing their DNA, is also at work, and probably to a much greater degree than ever suspected.

The findings, published recently in the journal Nature Genetics, strongly suggest that an unknown number of genes - over and above those affected by mutations - are involved in the cancer process.

"Science has been studying...

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Source: Cancer Weekly (2000-03-28)

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