Cancer Gene Therapy
Ribozyme Inhibits Delta EGFR and Reverses Malignant Phenotype
Published in Cancer Weekly, March 28th, 2000
"The goal of this study was to evaluate the activity of certain hairpin ribozymes against Delta EGFR messenger (m)RNA in glioblastomas multiforme (GBMs)," wrote M.E. Halatsch and colleagues, University Gottingen, Germany. "A distinct 801-bp deletion mutation associated with amplification of the EGFR gene is present in a large subgroup of primary GBMs and confers enhanced tumorigenicity in vivo."
Halatsch et al. published...
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Source: Cancer Weekly (2000-03-28)
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