Published in Cancer Weekly, March 28th, 2000
When the enzyme Chk2 is missing or defective, the "brakes" on proliferation of DNA-defective cancer cells are released and the cells are free to multiply and possibly form tumors. Since Chk2 normally activates p53, a gene that is mutated in more than half of human cancers, the researchers speculate that mutations in Chk2 could also cause cancer.
"These findings that Chk2 mutations behave like p53 mutations in causing cancer is very important," said Stephen Elledge, an Howard Hughes Medical...
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