Cancer Gene Therapy

Cytokine Gene Therapy Uses Fibroblasts to Enhance Tumor Immunity

Published in Cancer Weekly, April 4th, 2000

Cytokine gene therapies can make use of fibroblasts and dendritic cells to enhance tumor immunity.

"Recombinant interleukin (IL)-2 administration can mediate regression of solid tumors in patients with melanoma and renal cell carcinoma," stated M.T. Lotze and colleagues, University of Pittsburgh, Pennsylvania, USA. "A better understanding of the mechanisms of IL-2-mediated antitumor effects has led to the investigation of novel immunotherapeutic approaches. The rationale for these immunotherapeutic approaches and the results of preliminary clinical studies are presented" ("Interleukin-2: Developing additional cytokine gene therapies using fibroblasts or dendritic...

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Source: Cancer Weekly (2000-04-04)

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