Adoptive Immunotherapy

Gene Gun Generates Effector T Cells for Adoptive Therapy

Published in Cancer Weekly, April 4th, 2000

Using the gene gun for plasmid bombardment induces generation of effector T cells.

"We utilized the gene gun to transfect subcutaneous D5 melanoma and MT-901 mammary carcinoma tumors in situ with a granulocyte/macrophage-colony-stimulating factor (GM-CSF) plasmid complexed to gold particles," stated K. Tanigawa and colleagues from the University of Michigan, USA. "There was diminished tumor growth following bombardment with GM-CSF plasmid, which was apparent only during the period of administration."

Tanigawa et al. published the results of their study in the journal Cancer Immunology Immunotherapy ("Gene gun application in the generation of...

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Source: Cancer Weekly (2000-04-04)

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