Cell Cycle Regulation

Atomic Structure of Cancer-Protecting Protein Determined

Published in Cancer Weekly, April 4th, 2000

Agouron Pharmaceuticals, Inc., La Jolla, California, announced that its scientists have solved the atomic structure of a protein that plays a critical role in cell cycle regulation.

This protein, checkpoint kinase I (Chk1), is pivotal in a step of cellular regulation that protects cancer cells from damage caused by chemotherapy and radiation, common anticancer treatments. The structure of Chk1, determined by X-ray crystallography to a resolution of 1.7 Angstroms, was being reported in the March 17, 2000, edition of Cell.

The discovery is expected to contribute importantly to the development of new drugs for treatment of cancer, according to...

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Source: Cancer Weekly (2000-04-04)

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