Cancer Therapies

MAb Conjugates Combined with Chemotherapy Enhance Tumor Kill

Published in Cancer Weekly, April 11th, 2000

Polymeric drugs based on conjugates of synthetic and natural macromolecules demonstrated enhanced anticancer activity when combined with chemotherapy, researchers in the Czech Republic reported.

"We provide data on in vivo targeting of the Thy 1.2 (CDw90) cell surface receptor expressed on neoplastic T cells, mouse EL4 T-cell lymphoma," wrote B. Rihova and colleagues, Academy Sciences Czech Republic, Institute Microbiology ("Polymeric drugs based on conjugates of synthetic and natural macromolecules. II. Anti-cancer activity of antibody or (Fab ')(2)-targeted conjugates and combined therapy with immunomodulators," Journal of Controlled Release,...

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Source: Cancer Weekly (2000-04-11)

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