Melanoma
Mutation in the 5' UTR May Increase Susceptibility
Published in Cancer Weekly, May 16th, 2000
Though many cases of melanoma are partially due to mutations of CDKN2A at 9p21, a large number of affected families have 9p21 linkage but no CDKN2A mutation.
M. Harland and colleagues at St. James University Hospital in England investigated the possibility that these familial susceptibility to melanoma is due to mutations in noncoding regions ("Mutation screening of the CDKN2A promoter in melanoma families," Genes Chromosomes & Cancer, 2000;28(1):45-57).
The researchers studied 107 families with melanoma susceptibility. They evaluated the gene from the start...
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Source: Cancer Weekly (2000-05-16)
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