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Melanoma

Peptide-Pulsed Dendritic Cells Induce Immune Response Against Skin Cancer

Published in Cancer Weekly, May 16th, 2000

Peptide-pulsed dendritic cell vaccines induced antigen-specific immune responses in melanoma patients, reported researchers from the United Kingdom.

"Dendritic cells (DC) are professional antigen presenting cells (APC) that can be used for vaccination purposes in order to induce a specific T-cell response in vivo against melanoma-associated antigens," according to A. Mackensen and colleagues from the Freiburg University Medical Center, and the Institute of Molecular Medicine, United Kingdom. "Here we report on immunological responses in melanoma patients induced by vaccination with peptide-pulsed DC generated in vitro from CD34+ hematopoietic progenitor...

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