Leukemia

AML1 Gene May Be Target in 21q22 Amplicon

Published in Cancer Weekly, May 23rd, 2000

AML1 could be a target gene in the amplification in the 21q22 chromosomal region observed in pediatric acute lymphoblastic leukemia (ALL), researchers say.

Building on previous work, in which they identified a large amplicon in 21q22 in two cases of pediatric ALL, T. Niini and colleagues at the University of Helsinki in Helsinki, Finland, sought to find whether the AML1 gene, located in the same region as the amplicon, could be a target gene for the amplifications.

The researchers employed fluorescent in situ hybridization (FISH) to study bone marrow from 112 children with ALL. A dual-color AML1- and TEL-specific DNA probe was used to find the copy...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Cancer Weekly

Source: Cancer Weekly (2000-05-23)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry