Aging

Cellular Senescence Pathway Associated with Important Human Tumor Suppressor Gene

Published in Cancer Weekly, May 23rd, 2000

Lexicon Genetics Inc., The Woodlands, Texas, announced the publication of research describing a gene that controls how quickly mice age and its relationship to a pathway of cancer suppression in humans.

Lexicon scientists used proprietary technology to disrupt or "knock out" the Ku80 gene in mice, which resulted in mice that aged more than twice as fast as normal mice. This reduced the life span of the knockout mice to an average of only nine months as compared to about two years for normal mice. The Ku80 gene was found to function as part of a cellular senescence pathway controlled by the p53 tumor suppressor gene, one of the most commonly mutated genes in...

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Source: Cancer Weekly (2000-05-23)

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