Published in Cancer Weekly, May 23rd, 2000
Lexicon scientists used proprietary technology to disrupt or "knock out" the Ku80 gene in mice, which resulted in mice that aged more than twice as fast as normal mice. This reduced the life span of the knockout mice to an average of only nine months as compared to about two years for normal mice. The Ku80 gene was found to function as part of a cellular senescence pathway controlled by the p53 tumor suppressor gene, one of the most commonly mutated genes in...
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