Prostate Cancer

Effect of Linomide on Tumor Growth and Metastasis in an Animal Model

Published in Cancer Weekly, June 20th, 2000

Researchers in Germany recently studied the effect of linomide on tumor growth and metastasis in a human hormone-resistant prostate cancer cell line.

"It has been demonstrated that quinoline-3-carboxamide, linomide, inhibited angiogenesis and reduced the volume of tumors grown from human hormone-resistant prostate cancer cell lines after subcutaneous implantation in mice. However, subcutaneous xenograft models may not mimic human conditions due to the absence of prostatic stromal cells at the ectopic site," stated A. Bex and colleagues from the University of Essen, Germany.

The authors studied 30 surgically-exposed athymic nude mice by injecting...

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Source: Cancer Weekly (2000-06-20)

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