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Anti-Angiogenesis

Vinblastine and VEGF Receptor-2 Antibody Cause Tumor Regression

Published in Cancer Weekly, June 20th, 2000

According to a study from Canada, a low dose combination therapy with vinblastine and vascular endothelial growth factor (VEGF) receptor-2 antibody induced tumor regression in an animal model.

"Various conventional chemotherapeutic drugs can block angiogenesis or even kill activated, dividing endothelial cells," stated G. Klement and colleagues, Sunnybrook & Women's College, Canada. "Such effects may contribute to the antitumor efficacy of chemotherapy in vivo and may delay or prevent the acquisition of drug-resistance by cancer cells. We have implemented a treatment regimen that augments the potential antivascular effects of chemotherapy, that is devoid of obvious...

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