Telomerase

Use in Cell Culturing Activates Oncogene

Published in Cancer Weekly, June 27th, 2000

Scientists report that using telomerase to extend the life-span of human tissue culture cells is associated with activation of the c-myc oncogene and thus may present some level of cancer risk if the cells are intended for therapeutic use in humans.

David Beach, of the Wolfson Institute for Biomedical Research, University College, London, United Kingdom, and colleagues reported these findings in the June 15 issue of Nature. Joining Beach in the study were Jing Wang of Genetica, Inc., Cambridge, Massachusetts, and Gregory Hannon of Cold Spring Harbor Laboratory.

The ends of chromosomes, called telomeres, consist of specialized repeated...

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Source: Cancer Weekly (2000-06-27)

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