Cancer Gene Therapy
p53 Gene Transfer Improves Chemosensitivity of Lung Cancer Cells
Published in Cancer Weekly, July 4th, 2000
"The infection of recombinant adenovirus expressing wild-type p53 (Ad-p53) to lung cancer cells that harbor mutant p53 genes improves their response to cis-diamminedichloroplatinum," wrote Y. Horio and colleagues, Nagoya University. "In this study, we tested whether this improvement in response is also seen in wild-type p53 (wt-p53)-containing cancer cells and whether this phenomenon is universal with other commonly used chemotherapeutic agents, including etoposide, 7-ethyl-10-hydrocycamptothecin, paclitaxel, and...
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Source: Cancer Weekly (2000-07-04)
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