Kaposi's Sarcoma

Herpesvirus Sabotages Immune System with a New and Unusual Strategy

Published in Cancer Weekly, July 4th, 2000

The virus associated with Kaposi's sarcoma sabotages the body's immune system in a novel and previously unsuspected way, University of California, San Francisco (UCSF), scientists report.

When the herpesvirus associated with Kaposi's sarcoma (KS) invades a cell, two of the KS virus genes direct the cell to remove sentries posted on the cell surface and ship them to the interior for destruction, the researchers report. The sentries - proteins of the major histocompatibility complex (MHC-1) - constitute one of the cell's major lines of defense, and would otherwise tag the invaders for quick attack by the host immune system.

Other viruses sometimes...

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Source: Cancer Weekly (2000-07-04)

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